Request for Proposal
Controlled Sustained Release Mechanisms for Hydrogels
Status: RFP is Closed
Request for Proposal
RFP Title
NineSigma, representing a Global Leader in medical devices, invites proposals for technologies that can be incorporated into, or onto, a hydrogel material to sustain release of polysaccharides from the surface of a medical device such as an ocular insert under specific conditions, and only when triggered by these conditions. The proposed approach must fulfill the condition that the device will be stored in aqueous media, potentially for an extended period of time, prior to use.
The RFP sponsor is a manufacturer of medical devices and is seeking improvements in sustained release that can be applied to their products. The challenge is to design a sustained release mechanism that is triggered only when placed in an ocular environment, and not during pre-use storage in aqueous media. The approach must also be compatible with the manufacturing environment for medical devices, including autoclaving or other sterilization mechanism. Ideally, any proposed approach would allow for programmable release of the polysaccharide from the hydrogel surface or matrix.
The desired technology must:
Preferred features
Possible approaches might include, but are not limited to:
The following approaches are not of interest:
Your response should address the following: